Are you looking for the best ergonomic mouse 2022? This guide will share the top AnxietyTech found ergonomic mice.

Best Ergonomic Mice

Mice Images






  • Wireless 2.4G

  • 3 DPI options

  • 5 buttons

VicTsing Vertical

  • Wireless 2.4G

  • 4 DPI options

  • 6 buttons

Logitech MX Vertical

  • Vertical design

  • Up to 4000 DPI

  • Rechargeable wireless

Amazon Basics GP7-BL

  • Compact wireless

  • Fast scrolling

  • 3 color choices

VicTsing Ergo Mouse

  • 2.4G wireless

  • 2400DPI

  • 6 color choices

Microsoft Sculpt

  • 2.4G wireless

  • Thumb scoop design

  • Works on any surface

Logitech MX Master 2S

  • Wireless

  • Hyper fast scrolling

  • Rechargeable

Nulaxy ML13

  • Vertical wireless

  • 3 adjustable DPI options

  • 6 buttons

Redragon M602

  • Wired

  • RGB lighting

  • 7200DPI

Kensington K75575WW

  • Wireless 2.4GHz

  • 5 DPI options

  • Four buttons

1. Anker 2.4G Wireless vertical ergonomic mouse.

Anker 2.4G Wireless vertical ergonomic mouseThis mouse comes with a very sleek scientific design that is intended to encourage a healthy neutral wrist position. It also makes your arm feel more comfortable and allows for smoother movement and a lot less strain.

It comes with a few levels of DPI, the highest one being 1600. The resolution optical tracking technology is designed to deliver more sensitivity compared to traditional optical mice. This allows for smooth and precise tracking and it also makes it usable on a wide range of different surfaces. The mouse comes with added next and previous buttons for convenient webpage browsing.

Additionally, the mouse enters a power-saving mode after eight staying idle for eight minutes, making its battery last comparatively longer. It uses one 2.4 GB USB receiver which is contained in the bottom compartment of the mouse.


  • Ergonomic vertical design, stops you from twisting your wrist to use it
  • Build quality feels premium
  • Optical sensor works on all surfaces including glass


  • Back and forth buttons are poorly placed and sometimes hard to reach if you have smaller hands
  • The surface of the mouse can be quite slippery

2. VicTising ergonomic 2020 classic mouse.

VicTising ergonomic 2020 classic mouseThis mouse is dedicated to improving and alleviating the fatigue you might be feeling when using a regular one. It takes advantage of the exclusive 54-degree vertical angle which encourages a healthy wrist and forearm posture, hence reducing both strain and numbness.

It has four different DPI levels at 1000, 1600, 2000, and 2400, making it very easy for you to change the cursor speed and to adjust the overall sensitivity of the mouse. It also has back and forward buttons which will help you with browsing through webpages. In essence, it’s designed to improve your efficiency.

It’s also made of materials that are friendly to your skin and it’s very smooth to the touch. It has a size of about 5 x 3 x 2.8 inches and it weighs 14 ounces. The overall design of the mouse will help you reduce wrist pain which is easily caused by prolonged usage. It’s our second favorite mouse around.


  • Comfortable design
  • Responsive and accurate
  • Tracking and scroll wheel is precise
  • Four different DPI levels


  • May suffer from durability issues in the long run
  • Build quality doesn’t feel the most “premium”

3. Logitech MX Vertical wireless mouse.

Logitech MX Vertical Wireless MouseThe ergonomic design of this mouse allows you to place your hand in a natural handshake position. It uses a rather unique angle of 57 degrees, which prevents forearm twisting and it reduces muscle strain.

Now, the Logitech mouse can be connected to your Windows or Mac in three different ways – there’s an included USB c-charging cable, a USB unifying receiver or a standard Bluetooth technology. The battery is rechargeable and it can easily stay powered up for a total of a few months on a full charge.

It has an interesting capacity to navigate seamlessly on three different computers, copy-paste text, images, and files from one to another using the company’s Flow technology. It has a 4000 DPI high-precision sensor, making it a lot less challenging to track the mouse and move it on various surfaces.


  • Fits well in large hands
  • The angle of the mouse fits your handy perfectly and is very comfortable
  • Buttons require a light touch and are responsive
  • Cursor placement is accurate


  • Placement of the thumb buttons can be troublesome
  • Lack of up to date drivers for Mac users

4. AmazonBasics compact ergonomic mouse.

Amazon Basics Compact Ergonomic Wireless PC MouseThis is a very compact wireless mouse which allows for speedy and smooth navigating through various large documents and web pages. This is thanks to the forward/back thumb buttons, as well as its clickable and it has a fast scroll wheel.

The ergonomic mouse doesn’t support Bluetooth and it uses a 2.4 GHz wireless connection with a 33-foot range. It uses AES-128 encryption for additional security and it takes advantage of a very small USB receiver that can remain ported into your computer without obstructing any other ports. The optical sensor is convenient and it works on most surfaces.

In terms of its design, the ergonomic profile fits perfectly in the palm of your hand, which allows for additional comfort when using. It’s not a vertical design but it’s good enough for those who are used to traditional-style mice. In addition, you can also activate the fast-scrolling capability using a button in the middle to go even quicker through different documents or pages.


  • Feels good in the hand
  • Thumb rest is comfortable 
  • Extra buttons located by your thumb
  • Uses blue light and tracks well on any surface
  • Wireless connection
  • Competitively priced


  • Optimized for right handed users, would be nice to have one for left handed users
  • No DPI settings
  • Sometimes the connection can drop

5. VicTising wireless Ergo mouse.

VicTsing Wireless MouseThis is an affordable solution for those who are looking for a mouse with a comfortable ergonomic design. The company claims to have sampled thousands of palms to come up with the final design. It has a streamlined arc and thumb rest which should reduce the stress that’s caused by using a mouse for a prolonged period of time.

The battery life of this ergonomic mouse is supposedly up to 15 months. However, it will go into sleep mode in case you don’t use it for more than 8 minutes straight. After that, you can activate it by pressing any button.

It’s very easy to use and you can just plug the receiver into your laptop and start using it. In terms of DPI, it supports five different levels: 800, 1200, 1600, 2000, and 2400. You can change the sensitivity very quickly and also take advantage of the two side buttons to control the pages that you are browsing through.


  • Quick connection with easy setup
  • Easy to use
  • Has a long battery life
  • The response time is quick
  • Cheaply priced
  • Clicks are responsive


  • DPI randomly resets sometimes
  • Battery dies without warning its low or to recharge
  • Only works with desk/mousepad surfaces

6. Microsoft Sculpt L6v-00001.

Microsoft Sculpt Ergonomic MouseComing with a mid-range price tag, this mouse uses an advanced ergonomic design with a thumb scoop that is intended to encourage natural hand and wrist postures. This is particularly important for people who work with a computer continuously and don’t want to experience any strain or numbness in their wrists and forearm.

The mouse angle and its height are designed to place your wrist in a very specific and comfortable way. Meanwhile, the MicrosofTrack Technology that the device is equipped with gives you precise control on the majority of surfaces. Some users, however, report that it doesn’t work well on polished countertops.

It’s also equipped with a Windows button which will give you one-touch access to the Start Menu. Of course, this is limited to users who take advantage of Microsoft’s operating systems.


  • Very comfortable design
  • Scroll wheel is smooth and responsive
  • Thumb grip is great
  • The mouse cover on the bottom is magnetic


  • USB receiver is very large, so it’s awkward to transport
  • Glossy plastic can get sticky after a while of using it

7. Logitech MX Master 2S.

Logitech MX Master 2SOne of the more interesting features of this mouse is that it has cross-computer control. This means that you can change the capacity to navigate conveniently on three different computers, allowing you to copy-paste text, images, and files from one to another.

In other words, you can use up to three Mac or Windows computers with a single unifying receiver or Bluetooth Smart wireless technology.

In terms of design, the handcrafted shape is intended to support your wrist and hand in a very comfortable position that is quite natural. This is paramount for prolonged usage. The mouse uses a rechargeable Li-Po (500 mAh) battery and you can use it for many days on a single charge.


  • Thumb rest is very comfortable
  • Free scroll setting for scroll wheel is smooth
  • Customizability of Logitech software is great
  • Wireless connectivity so no wires


  • Mouse can be quite loud in normal mode
  • If your not used to the larger grip it may feel awkward and take time to get used to

8. Nulaxy Vertical Mouse.

Nulaxy Vertical MouseThis is another budget-friendly option for those of you who are looking for a nice ergonomic mouse. The design is very comfortable and, much like others on our list, is intended to provide a natural and healthy handshake wrist and arm position. This should increase your precision when browsing through documents or the Internet and should also reduce the strain in your wrist and forearm muscles.

Additionally, the mouse is compatible with various operating systems such as Windows, Mac, and Linux. It can be used with a laptop or a personal computer.

It’s equipped with a multifunction button that works as a DPI switch so that you can easily change the cursor speed. This is particularly convenient for a variety of applications. Of course, being in the budget range, some users have reported a few complaints of minor malfunctions like double-clicks. However, it does come with three different DPI levels and you can switch between 800, 1200, and 1600.


  • Fantastic frustration free packaging
  • Set up is very easy
  • Mouse feels great in hands
  • Multiple DPI settings


  • Doesn’t include batteries
  • Doesn’t say the current DPI level when in use
  • Only for right handers

9. Redragon M602 RGB.

Redragon M602 RGBLargely promoted as a gaming mouse, this particular one caters to MMO users thanks to the programmable buttons. In other words, you can fix the mouse in a way that perfectly suits your own gameplay.

The gaming mouse is a budget-friendly option and it works well with Windows, Linux, and MAC operating systems. It should also work very well with the major gaming computers and laptops. It comes with multiple DPI sets – you can choose between 800, 1200, 1600, 2400, and 7200 DPI based on your own play style.

Moreover, the design is rather comfortable. Even though it has a blacklight, it can be disabled if you find it annoying. It also has 5 memory profiles and each one of them comes with a distinct LED color option so that you will be able to identify them quicker.

Gaming mice aren’t designed for office use, so you won’t want this RGB lit up mouse in your office. Also they don’t offer a degree angle that is comfortable. The mouse is designed for gaming purists, although if you can’t do the 70 days of learning the vertical option, then this might be for you.


  • Vibrant RGB colors
  • DPI settings
  • You can map macros on the mouse
  • Several customizable buttons are remappable
  • Has great packaging
  • Priced cheaply


  • Software is hard to find and rather clunky
  • Mouse can be slightly small for large hands
  • Thumb grip is quite slippery

10. Kensington K75575WW.

Kensington K75575WWThe first thing to note about this mouse is that users are able to select different DPI levels (1200, 1600, 2000, and 2400) using a single button. This allows for on-demand precision whenever you may need it.

It comes with four different buttons, including back-and-forward so you can browse through different web pages with ease. It’s another budget-friendly option for those looking for a good vertical mouse with an amazing design.

Speaking of design, the mouse uses an angled slope which will keep your wrist in a comfortable position. This will help relieve the compression of soft tissue and it should also improve your overall wrist and forearm posture. It’s 2.74 inches tall and about 4.38 inches long. It comes with extended lip support for your little finger. This should enable additional comfort when it comes to longer mouse strokes.


  • Comfortable hand positioning
  • Mouse moves smoothly
  • Battery operated, doesn’t require rechargeable batteries
  • Competitively priced
  • Simple design and pratical for basic use


  • The left/right click buttons can feel tough when pressing
  • The clicking is also very loud
  • The mouse leaks red light from the sensor out the front which can be a little annoying

What are some other honorable mentions for ergonomic mice?

  • Logitech MX Ergo Trackball Mouse
  • Logitech MX Master 3
  • Penguin Ambidextrous Vertical Mouse
  • ELECOM 2.4GHz Wireless Finger-Operated Trackball Mouse

Vertical or horizontal mouse?

Vertical. In our opinion the best vertical mouse is way more comfortable, ergonomic and easy to use compared with horizontal mice. When it comes to a gaming mouse, we recommend horizontal. Vertical mice sometimes come with a wireless trackball too, which can be very useful.

Why are most ergonomic mice vertical?

Having a mouse that’s vertical allows your hand to be in a natural position. It’s easier to move the mouse, reduces carpal tunnel, is easier for small hands and is more comfortable overall. The only issue is the lack of left handed mice and sometimes the awkward positioning of extra mouse buttons.

Should I get a ergonomic or traditional mouse?

A traditional computer mouse might be the best mouse for you, but it depends. If you have hand issues or pain in your wrist, you’d want to opt for an ergonomic option, such as the Logitech Ergo range. People find ergonomic options as the more comfortable mouse and trackball mice are often used in office or design work.

Wireless or wired?

A wireless option will require you to remember a USB dongle, AA batteries, AAA batteries or even a rechargeable battery. Replacing these can be annoying. You’ll also need to connect via Bluetooth which requires a dongle or a compatible device. For long term use, I’d say pick the most comfortable to use, but if you have two of the same go with wired.

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